The

Promise of

Interleukin-2

Therapy.

13-16 Nov. 2019

For autoimmune and inflammatory diseases, allergy, transplantation and cancer

Centre international de Conférences Sorbonne Université

4 place Jussieu - Patio 44-55

75005 - Paris, France

*To submit before the 15 sept. 2019

Confirmed Speakers

(by alphabetical order)

Abul K.  Abbas, Andre Ballesteros-Tato, Christophe Benoist, Jeffrey Bluestone, Jen Bon Lui, Onur Boyman, Michael Farrar, Garrison Fathman, Jason Fontenot, Agnes Hartemann, Jens Humrich, David Klatzmann, John Koreth, Vijay Kuchroo, Claude Le Pen, Zhanguo Li, Loui Madakamutil,  Thomas Malek, Encarnita Mariotti-Ferrandiz, Alexander Marson, Tewfik Miloud, Francisco Ramirez-Valle, Jerome Ritz, Michelle Rosenzwajg, Alberto Sanchez-Fueyo, Scott Snapper, Naomi Taylor, Nadia Tchao, Georges Tsokos, Harikesh Wong, Jonathan Zalevsky, Zinan Zhang

 

Saturday 16th

8.30 am

Session VII

IL-2 and Treg cell therapies

Chair : M. Sadelain

 

- Lessons from CAR T cell in Cancer

M. Sadelain

- Current status of unmodified Treg therapy trials

Q. Tang UCSF

- CAR-Tregs

S. Boissel, TxCell

- Orthologs

2-3 talks from abstracts (including IL-2 engineered Tregs : ILTOO)

Session VII - Novel IL-2s (Chair: D Klatzmann)

1.Nektar (N…) (also covering IL2 and cancer)

2.Celgene (N…)

3.Roche (N…) 

4.ILTOO (J Mariau)

5.2-3 talks from abstracts

Coffee Break

Welcome reception

Saturday 16th

9.00 am

Session VII

 IL-2 and Treg cell therapies: competing or complementing? 

Chair : J. Fontenot

 

1. The future of Treg therapy (J. Bluestone)

2. CAR-Tregs (J. Fontenot) 

3. Treg activation and energetic and biosynthetic demands (N. Taylor)

4. IL-2 self-suficient Tregs (T. Vazquez)

5. Talks from abstracts 

11.00 - 11.30 am

Coffee Break

Session V.b

Novel IL-2s 

Chair : J. Mariau

 

1. Treg expansion via IL-2 mutein (F. Ramirez-Valle)

2. IL-2/CD25: A long-acting IL-2-based fusion protein that suppresses autoimmunity (J. Bon Lui)

3. Novel first in class Il-2-drug conjugate to enhance/restore the defective Treg IL-2R function (G. Fathman)

1.00 pm

Afterwords

 

The Promise of Interleukin-2 Therapy.

13-16 Nov.

2019

13-16 Nov.

2019

Centre international de Conférences Sorbonne Université

4 place Jussieu - Patio 44-55

75005 - Paris, France